Brenner san diego

Brenner has also studied trans-cultural and integrative healing in South America, Taiwan, and China. He believes the answer can finally be found in the new field of Epigenetics — the study of those environmental factors that affect the expression of a gene.

He is a member of the Life Wellness Institute of San Diego and a consultant for Praxis Creative Leadership Systems, which specializes in executive coaching, team building, and organizational leadership development. He has appeared on Public Television and moderated the award-winning K.

S series, Healing Through Communication. Brenner received his B. He received his Ph. Paul Brenner Videos Links Care for a snippet of history? More About Dr. Brenner Dr. Brenner was fantastic in every way. He completely understood the facts and made my clients feel at ease — they loved him! Brenner: Thank you so much for conducting the mediation yesterday and your kind words.

My clients are very pleased with the result. He thought you did a terrific job during mediation. I will definitely keep you in mind for future mediation sessions. I hope that I have the opportunity to work with Jon in the near future.

Brenner was very well prepared. He clearly read the briefs and was familiar with complex and unique legal issues. I would recommend him due to his knowledge, experience, ability to empathize and communicate personally. Read More. Additionally, Mr. Los Angeles Mediation. Sacramento Mediation. San Diego Mediation. San Francisco Mediation. Using nascent RNA sequencing to detect transcription rates at enhancer elements to measure enhancer activity.

Cell-type and stimulus specific gene expression is often modulated by promoter-distal enhancer elements, but the exact mechanisms by which these regulatory features function and influence the expression of nearby genes is poorly understood. We study these processes within the context of cellular differentiation and innate immune signaling in the hematopoietic lineage, attempting to link the activation of enhancers with functional consequences in the immune system.

We are also investigating the effect of natural and disease-associated genetic variation on enhancer function to better understand the impact that non-coding DNA has on regulatory networks. Developing software and innovative approaches to analyze Hi-C data and integrate with transcriptome and epigenetic data.

The structural configuration of chromatin in the nucleus plays an important role in regulating gene expression. We have worked extensively with the Heinz laboratory at UCSD to develop software and innovative approaches to analyze Hi-C data and integrate it with transcriptome and epigenetic data. Changes in genome structure are important determinates for cellular differentiation and have important implications during the immune response.

The genome structure underlying the adaptive immune system not only orchestrates tightly controlled patterns of gene expression, but must also facilitate the functional recombination of antigen receptor loci. A deep understanding of these processes is important to understand B and T cell function and how Ig and TCR loci are capable of generating diverse repertoires of receptors to combat disease. Leveraging genome-wide technologies and bioinformatics analysis to study transcriptional networks.

We participate in multiple projects studying innate immunity, leveraging genome-wide technologies and bioinformatics analysis to better understand transcriptional networks regulated by Toll-like receptors and anti-viral pathways. We study how the interplay between key inflammatory transcription factors e. In particular, we are very interested in how viruses influence regulatory mechanisms to subvert cellular defenses, including global effects on transcription termination, splicing, and RNA stability.

Applying NGS techniques across non-modal organisms to study changes in transcription initiation architecture. We are studying the evolution of eukaryotic transcription by applying advanced NGS techniques across a large number of non-model organisms to study changes in transcription initiation architecture.

In close collaboration with Sascha Duttke in the Glass lab at UCSD, we are working to map the precise locations of transcription initiation across a broad range of eukaryotes and understand the diversity and conserved properties of both protein coding and ncRNA promoters across evolution.

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development Nature Communications Apr J Lipid Res. Protein Cell. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. MHC class II proteins mediate cross-species entry of bat influenza viruses. Diverse motif ensembles specify non-redundant DNA binding activities of AP-1 family members in macrophages. A longitudinal systems immunologic investigation of acute Zika virus infection in an individual infected while traveling to Caracas, Venezuela.

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. Cell August Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling Nature Comm. J Clin Invest. Nucleoporin-mediated regulation of cell identity genes. Genes Dev. Nascent RNA sequencing reveals distinct features in plant transcription. Emergence of a Homo sapiens-specific gene family and chromosome 16p J Cell Biol. Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. BRD4 is a novel therapeutic target for liver fibrosis. Perspectives on Unidirectional versus Divergent Transcription.